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STTK:NASDAQShattuck Labs, Inc. Analysis

Data as of 2026-06-03 - not real-time

$4.87

Latest Price

8/10Risk

Risk Level: High

Executive Summary

Shattuck Labs (STTK) is trading at $4.87, well below its analyst consensus target of $12.50, implying a potential upside of over 150%. The stock is technically oversold with an RSI of 26 and sits just above a near‑term support level of $4.79, while the MACD remains bearish, suggesting limited short‑term momentum. Volatility is extreme at nearly 69% over the past 30 days and a beta of 1.6 points to heightened sensitivity to market swings. Fundamentally, the company reports negative margins, a loss‑making EBITDA of $‑48.9 M and a forward PE of –9.5, reflecting its clinical‑stage status, yet it holds $90 M in cash against modest debt of $2.9 M, providing a comfortable runway. Recent material news confirms completion of Phase 1 enrollment for SL‑325 and the planned initiation of a Phase 2 trial in Crohn’s disease later this year, which could act as a catalyst. While the biotech sector carries intrinsic regulatory and execution risk, the company’s unique DR3‑targeted antibody platform offers a differentiated growth narrative. The combination of a deep cash position, low leverage, and a sizable upside target makes the stock appear undervalued despite its earnings deficits. However, the absence of revenue growth and ongoing cash burn temper enthusiasm. Investors should weigh the near‑term technical weakness against the medium‑term clinical milestones. In summary, STTK presents a high‑risk, high‑reward profile where upcoming trial data could unlock significant value, but the current price reflects the market’s caution.

Market Outlook

Short Term

< 1 year
Neutral
Model confidence: 5/10

Key Factors

  • RSI indicates oversold conditions but MACD remains bearish
  • Price is near technical support with limited upside until trial data
  • High volatility and beta increase short‑term price swings

Medium Term

1–3 years
Positive
Model confidence: 7/10

Key Factors

  • Phase 1 data expected Q2 2026 and Phase 2 initiation Q3 2026 could drive catalyst
  • Substantial cash runway reduces financing risk
  • Analyst target price suggests >150% upside

Long Term

> 3 years
Positive
Model confidence: 8/10

Key Factors

  • Unique DR3 antibody platform offers differentiated growth potential
  • Low debt and strong cash position support continued R&D
  • Long‑term market opportunity in inflammatory and immune‑mediated diseases

Key Metrics & Analysis

Financial Health

P/E Ratio-9.5
ROE-61.04%
ROA-36.66%
Debt/Equity3.02
P/B Ratio3.8
Op. Cash Flow$-41274000
Free Cash Flow$-22423376
Industry P/E27.0

Technical Analysis

TrendNeutral
RSI26.0
Support$4.79
Resistance$7.29
MA 20$6.22
MA 50$6.66
MA 200$3.92
MACDBearish
VolumeStable
Fear & Greed Index93.27

Valuation

Target Price$12.50
Upside/Downside156.67%
GradeUndervalued
TypeGrowth

Risk Assessment

Beta1.60
Volatility68.99%
Sector RiskHigh
Reg. RiskHigh
Geo RiskLow
Currency RiskLow
Liquidity RiskMedium

This analysis may contain inaccuracies and is provided for informational and research purposes only. It is not personal investment advice, a recommendation, or an instruction to buy, sell, or hold any asset.