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SPRO:NASDAQSpero Therapeutics, Inc. Analysis

Data as of 2026-09-01 - not real-time

$1.22

Latest Price

9/10Risk

Risk Level: High

Executive Summary

The moving-average structure behind Spero Therapeutics, Inc. is bearish at $1.22, with short-term averages lagging the long-term ones. Across the trailing 30 sessions it lost 15.3%. RSI sits at 37.7, which reads as approaching oversold, and MACD momentum is bullish. Price has been bracketed by support at $1.15 and resistance at $1.30.
Valuation screens as undervalued: a P/E of 8.7 sits below the sector average of 30.4. Consensus targets land 227.9% above where the shares trade now.
Risk comes out at 9 of a possible 10, a high reading. With 30-day volatility of 50.5%, a beta of 1.47 and a maximum drawdown of 61.4%, position sizing matters more than entry timing here. The wider market backdrop reads extreme greed at 93 on the fear-greed composite.
The horizons diverge: hold near-term but buy on a long view, at 5/10 conviction over the longer horizon.

Top Market Events

SPRO strengthens its balance sheet and extends cash runway into 2029 while advancing its new SP001 immunology pipeline...Yahoo Finance19dSpero Therapeutics Inc SPRO Q2 2026 Earnings Call Highlights: FDA Approval of Utebzi and .CAMBRIDGE, Mass., Aug. 04, 2026 GLOBE NEWSWIRE -- Spero Therapeutics, Inc. Nasdaq: SPRO , a clinical-stage...

Market Outlook

Short Term

< 1 year
Neutral
Model confidence: 1/10

Key Factors

  • Short-term moving averages stacked below long-term ones
  • Trading below the 200-day average of 2.24
  • MACD momentum is positive

Medium Term

1–3 years
Neutral
Model confidence: 3/10

Key Factors

  • Short-term moving averages stacked below long-term ones
  • P/E of 8.7 versus sector average of 30.4
  • Trading below the 200-day average of 2.24

Long Term

> 3 years
Positive
Model confidence: 5/10

Key Factors

  • P/E of 8.7 versus sector average of 30.4
  • Analyst targets imply +227.9% versus the current price
  • Profit margin of 15.7% is healthy

Key Metrics & Analysis

Financial Health

Profit Margin15.71%
P/E Ratio8.7
ROE19.17%
ROA7.19%
Debt/Equity4.62
P/B Ratio1.6
Op. Cash Flow$19.6M
Free Cash Flow$28.8M
Industry P/E30.4

Technical Analysis

TrendBearish
RSI37.7
Support$1.15
Resistance$1.30
MA 20$1.22
MA 50$1.54
MA 200$2.24
MACDBullish
VolumeDecreasing
Fear & Greed Index93.09

Valuation

Fair Value$7.14
Target Price$4.00
Upside/Downside227.87%
GradeUndervalued
TypeBlend

Risk Assessment

Beta1.47
Volatility50.48%
Sector RiskMedium
Reg. RiskHigh
Geo RiskLow
Currency RiskLow
Liquidity RiskMedium

This analysis may contain inaccuracies and is provided for informational and research purposes only. It is not personal investment advice, a recommendation, or an instruction to buy, sell, or hold any asset.